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Rating one of the best betaine HCl dietary supplements of 2021

Betaine HCl is a complement that may assist acidify your abdomen and enhance digestion, particularly when the digestive enzyme pepsin is added.

In a standard, wholesome abdomen, your abdomen acid is very acidic, which lets you quickly and successfully break down the meals you eat into digestible vitamins, nutritional vitamins, and minerals.

Nevertheless, some folks have low abdomen acidity, which hurts their capacity to effectively digest the meals they eat. This will trigger indigestion and different gastrointestinal issues.

Taking a betaine HCl complement can assist the scenario by including extra acidity to your abdomen. When pepsin is added to the combo, digestion can enhance even additional. Our researchers have ranked the ten greatest betaine HCl dietary supplements in the marketplace based on their effectiveness.


1. NOW Betaine HCl

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NOW Betaine HCl makes use of a reasonably customary and robust dose of betaine HCl. Every capsule’s acquired 648 mg, however what makes this complement distinctive is its use of a special digestive enzyme, protease.

This enzyme, like pepsin, additionally helps break down proteins, however it accomplishes it by way of a special mechanism.

Using this enzyme as an alternative of pepsin might make this complement a powerful alternative if different betaine HCl and pepsin dietary supplements aren’t working for you.

2. Solaray Excessive Efficiency HCl + Pepsin

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Solaray makes an HCl complement delivered utilizing a cellulose capsule that’s acquired a reasonably sturdy dosage of 650 mg of betaine HCl per serving, together with 162 mg of the digestive enzyme pepsin.

It’s a reasonably easy and easy formulation that’s broadly used and really efficient.

3. Dr. Clark Betaine HCl

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Dr. Clark Betaine HCl is the way in which to go in order for you an especially pure HCl complement and also you explicitly do not need any enzymes added to it. Every gelatin capsule incorporates 425 mg of pure betaine HCl and nothing else.

Whereas this dosage is low, and there are many causes so as to add in pepsin or different digestive enzymes to a digestion complement, this product is unquestionably one of the best choose for betaine HCl by itself.

4. Finest Naturals Betaine HCl

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Finest Naturals Betaine HCl has a reasonably customary 648 mg of betaine, however what makes this complement distinctive is the excessive pepsin content material.

At 150 mg per capsule, this digestive enzyme is present in far larger concentrations on this complement than in lots of rivals. If an everyday betaine HCl complement isn’t doing the trick, attempt upping the pepsin content material with Finest Naturals.

5. Premier Analysis Labs Premier HCl

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Premier Analysis Labs makes an HCl complement that depends on a cellulose capsule for supply, and given the absence of pepsin or different enzymes (that are invariably derived from animal sources), that makes this the one actually vegetarian and vegan-friendly HCl complement price a glance.

Every capsule has a reasonable dose of 500 mg of betaine HCl, so whereas it’s not essentially the most potent complement on the market, it should get the job accomplished for many individuals.

6. Physician’s Finest Betaine HCl Pepsin and Gentian Bitters

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Physician’s Finest has a digestive complement that goes the additional mile by together with the extract of the gentian plant, which is native to Europe and has traditionally been used as an natural treatment for digestive points.

The scientific proof supporting the usage of betaine HCl and pepsin is stronger, although, so until you are feeling such as you want one thing additional, a extra conventional digestive complement is likely to be a greater place to begin.

7. Pure Encapsulations Betaine HCl Pepsin

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Pure Encapsulations has a reasonably center of the street lower-dose digestive complement. With 520 mg of betaine HCl and 21 mg of pepsin per capsule, it’s a good match in case you are searching for a decrease dosage answer, however other than that, most individuals would profit from the next dose complement, not less than to begin with.

On the intense aspect, the complement design is pretty clear, with out a lot in the way in which of pointless components.

8. Thorne Analysis Betaine HCl and Pepsin

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Thorne Analysis makes a extra moderately-dosed betaine HCl complement. Every capsule has 500 mg of betaine HCl, together with 24 mg of pepsin.

It’s acquired just a few extra components than you would possibly prefer to see, however the decrease dosage might be helpful in case your abdomen acid ranges are solely barely low and also you don’t wish to overdo it with a stronger complement.

9. Important Vitamins Betaine HCl Pepsin Gentian Root Extract

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Important Vitamins provides a betaine HCl complement that, like just a few different merchandise, contains gentian root extract alongside pepsin in an try to spice up its digestive energy.

The principle downside with this complement is that the pepsin content material is decrease than many related dietary supplements, as a result of it’s offered in a 1:15,000 ratio as an alternative of the extra widespread and extra extremely concentrated 1:10,000 ratio.

Which means the efficient dose per capsule is 50% much less, so in case you are counting on the digestive energy of the pepsin enzyme, you is likely to be dissatisfied.

10. Pure Components Betaine HCl

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Pure Components swaps out the same old pepsin for fenugreek seed extract, a less-common natural extract that’s extra typically present in testosterone boosters and Ayurvedic complement regimens.

Whereas fenugreek does have a historical past of use for treating indigestion and gastrointestinal complains, it hasn’t been straight evaluated alongside betaine HCl the way in which pepsin has.

This, mixed with the presence of a pair additional binders and fillers, makes this digestion complement much less fascinating than another rivals.

Class winners

Finest betaine HCl general: NOW Betaine HCl

NOW Betaine HCl is our favourite general choose because of its excessive dose of betaine and its use of protease, a extremely efficient enzyme at breaking down proteins in your digestive tract. For that reason, it’s helpful each for augmenting your abdomen acidity and for combating digestion issues by way of enzymatic means. This two-in-one combo makes it our best choice.

Finest betaine HCl with pepsin: Solaray Excessive Efficiency HCl + Pepsin

Betaine HCl and pepsin are generally beneficial as a mixture complement for acid reflux disorder and different abdomen points, and when you’re particularly searching for the enzyme pepsin, Solaray is our suggestion because of its excessive dose of each betaine HCl and pepsin enzymes.

Finest betaine HCl for abdomen acidity: NOW Betaine HCl

NOW Betaine HCl makes use of its excessive dose of betaine HCl to spice up abdomen acidity, and on high of that, has an revolutionary method to assist digestion with protease. In case your purpose is to handle abdomen pH ranges which are too excessive (which means not acidic sufficient), NOW is an effective alternative.

Finest betaine HCl with out enzymes: Dr. Clark Betaine HCl

For many who desire a betaine complement with no added enzymes, Dr. Clark Betaine HCl is the way in which to go. Whether or not you take your individual digestive enzymes individually, otherwise you’re solely searching for betaine by itself, Dr. Clark supplies a pure and easy complement that matches the invoice.

Finest betaine HCl for fatigue: NOW Betaine HCl

Betaine HCl is changing into an more and more well-liked complement for folks with power fatigue, because of the connection between intestine perform and the immune and hormone techniques. For this software, our suggestion is NOW Betaine HCl, which does an ideal job of addressing abdomen perform with each betaine and protease.

Finest betaine HCl for acid reflux disorder: Solaray Excessive Efficiency HCl + Pepsin

Betaine HCl and pepsin are a traditional mixture for acid reflux disorder, and Solaray makes one of the best product in the marketplace that features each of those substances. This complement is a simple alternative in relation to acid reflux disorder.

Who can buy betaine HCl?

Betaine HCL is secure for most individuals and can assist improve abdomen acidity to assist individuals who endure from low abdomen acid. Betaine HCL might also be efficient for serving to to forestall coronary heart illness because it has been proven to decrease ranges of homocysteine. 

Pregnant and breastfeeding girls ought to communicate to their physician earlier than taking betaine HCL as there may be nonetheless an absence of analysis surrounding the protection in these populations. Individuals with peptic ulcer illness ought to keep away from betaine HCL as nicely since it could intrude with the therapeutic of abdomen ulcers.

How we ranked

We first seemed on the substances of every betaine HCL complement. We most well-liked merchandise that used minimal fillers, components, and binders to make sure nothing dangerous was being ingested. Moreover, we required all of our betaine HCL dietary supplements to include pepsin to enhance to boost digestion. Merchandise like Physician’s Finest ranked nicely for additionally offering 20mg of gentian to additional improve digestive assist.

Dosage was additionally vital to contemplate, for each the pepsin content material and the betaine HCL. In response to analysis, upwards of 500mg of betaine HCL is the minimal requirement for inflicting constructive abdomen acid modifications. As such, we most well-liked merchandise like NOW and Solaray that had much more, as this confirmed their dedication to offering clinically efficient dosages. 

By way of pepsin dosage, there aren’t any clear concusses on what is perfect. Nevertheless, primarily based on our examination, round 20mg per serving (or extra) of pepsin alongside betaine HCL appears to be secure and efficient. Because of this merchandise like Thorne made our checklist. 


Betaine HCl causes a fast improve in abdomen acidity. The acidic compounds in strong betaine HCl are designed to quickly dissolve in your abdomen and offered much-needed acidity for folks with low abdomen acid ranges.

So, how nicely and the way shortly does it work? That query was addressed in a scientific examine by researchers on the College of California San Francisco (1). Their examine, revealed within the journal Molecular Pharmaceutics in 2003, used wholesome volunteers who had artificially-induced low abdomen acid.

The topics swallowed a particular sensing capsule that straight measured their abdomen acidity, then after a delay, took 1500 mg of betaine HCl. Inside quarter-hour, the abdomen acidity in all the volunteers had rocketed from a pH of 5.2 right down to a pH of 0.6 (decrease values which means a extra acidic atmosphere).

Betaine HCl’s results final for about an hour and fifteen minutes. Due to the acidity monitoring capsule that this examine used, the researchers have been in a position to repeatedly observe the degrees of abdomen acidity as a perform of time.

They discovered that the pH-lowering results of betaine HCl lasted for about 75 minutes, after which abdomen acidity climbed again to its regular ranges.

The authors counsel that, due to these properties, betaine might be helpful for enhancing the absorption of medicines, nutritional vitamins, or minerals that depend on abdomen acid for absorption.

Usually, folks with poor abdomen acidity would have a tough time absorbing issues like a zinc complement, which frequently depend on abdomen acidity to make the energetic substances bioavailable.

In case you are taking pepsin, it’s best to take betaine HCl too. Pepsin is essentially the most vital digestive enzyme present in your abdomen; it helps break down an enormous vary of the compounds which are within the meals you eat.

In case you take a pepsin complement for indigestion or different gastrointestinal issues, you could not get the meant results when you aren’t additionally taking it alongside betaine HCl.

As reported by researchers researchers in Marseille, France and revealed within the journal Gastric Problems, the digestive powers of pepsin are best at low pH ranges (2)—once more, recalling that low pH equals excessive ranges of acidity.

Pepsin works greatest at excessive ranges of abdomen acidity. In order for you the optimum digestive energy from a pepsin complement, you should ensure your abdomen acidity is powerful sufficient.

For regular and wholesome folks, there shouldn’t be any points, however when you have indigestion or different points which are making you inclined to take a complement with pepsin, it’s attainable that suboptimal abdomen acidity might be contributing as nicely.

On this case, pepsin (in addition to some other digestive enzyme present in a pure and wholesome abdomen, together with pure probiotic micro organism) will perform significantly better within the presence of betaine HCl.

Betaine HCl could decrease ranges of homocysteine, a danger issue for coronary heart illness. One attention-grabbing unwanted effects of betaine HCl is that it seems to decrease ranges of a blood biomarker referred to as homocysteine.

Analysis out of the Netherlands experiences that betaine supplementation at excessive doses lowers homocysteine in each women and men when taken each day for six weeks (3). Since homocysteine is a danger issue for coronary heart illness, this implies that betaine HCl could also be helpful for coronary heart well being, too, although extra analysis is required.

Unwanted effects

As a result of betaine HCl causes such a fast and substantial improve in abdomen acidity, you shouldn’t use it when you don’t have indigestion.

A standard and wholesome abdomen would possibly get too acidic after a excessive dose of betaine HCl, although it’s attainable that pepsin would ameliorate this considerably. It’s additionally a poor alternative when you have acid reflux disorder illness, as a result of the newly-acidic abdomen acid can harm your esophagus much more severely.

Using a betaine HCl complement with pepsin is especially discouraged as a result of pepsin appears to be accountable for a lot of the harm related to acid reflux disorder illness.

In response to analysis by James A. Koufman revealed within the medical journal The Laryngoscope in 1991, the first trigger of injury to the esophagus in power acid reflux disorder illness is definitely pepsin, and never the hydrochloric acid (HCl) current in each abdomen acid and betaine HCl (4).

Additional work by Nikki Johnston and different researchers on the Medical Faculty of Wisconsin demonstrated why: the enzyme pepsin will get deposited on esophagus tissue throughout one acid reflux disorder occasion, and stays there dormant—the enzyme is deactivated in circumstances that aren’t extremely acidic (5). However when new acid flushes up the esophagus once more, it reactivates the pepsin which causes extra harm.

Except for folks with acid reflux disorder illness, pepsin might also trigger allergic reactions, although experiences of this are extraordinarily uncommon.

One report revealed in 2016 described such a case; the options of this case have been just like different allergic reactions to enzymes derived from plant or animal merchandise (6). Although terribly uncommon, it’s one extra aspect impact to pay attention to.

Really helpful dose

Direct medical suggestions on betaine HCl dosing are few and much between, and for pepsin they’re absent utterly. It’s clear that 1500 mg of betaine HCl is adequate to create a big improve in abdomen acidity in very brief order, however many individuals could not want such drastic swings in pH degree of their abdomen.

As an alternative, it’s most likely higher to begin with a decrease dose of betaine: 500 or 650 mg. If that’s adequate, then you may preserve the identical dosage, however in case you are nonetheless having digestion points, you could possibly improve the dose or get a complement with the next dose of pepsin (retaining in thoughts the caveats above relating to pepsin and acid reflux disorder).


How does betaine HCL profit the abdomen? Betaine HCl is a complement that may ship acidity to your abdomen in capsule kind. It’s designed in a intelligent method to make sure which you can improve your abdomen’s acidity, and thereby its digestive energy, with out being too dangerous to the remainder of your physique.

It’s extraordinarily efficient in relation to decreasing your abdomen acidity, and it could have ancillary advantages for coronary heart well being as nicely.

How do I do know if betaine HCl is correct for me? In case you endure from Hypochlorhydria, the place the abdomen produces a decrease quantity of acid, betaine HCl could also be best for you. It would be best to seek the advice of your physician to diagnose the situation, and so they can prescribe you an correct dose primarily based in your particular person well being. 

There aren’t any clear dosage requirements, so it’s vital to get a medical skilled’s opinion earlier than taking it. Typical doses vary from 300 to 650 mg throughout or close to the tip of a meal that’s protein-heavy. 

Can I take betaine HCl whereas pregnant or breastfeeding? There’s inadequate proof to counsel that betaine HCl is secure for pregnant or breastfeeding girls, so please seek the advice of your physician earlier than taking this complement in case you are anticipating. Relating to unknown dietary supplements and being pregnant, it’s higher to be secure and never take a complement than take it and trigger points together with your child. 

What occurs if I’m allergic to betaine HCl? In case you are allergic to betaine HCl, you could expertise widespread allergy signs like dizziness, nausea, itchiness, pores and skin rash, headache, swelling within the throat or tongue, or a basic feeling of being unwell. In case you have a unfavourable response after taking betaine HCl, please search medical consideration instantly. 

How will I do know if I’ve taken an excessive amount of betaine HCl? There’s not so much that’s recognized about correct dosage for betaine HCl, so recommendation out of your medical physician to find out dosage is crucial. In case you’ve taken an excessive amount of betaine HCl and your meal has a low quantity of protein, there will be an abundance of acid. 

In case you’ve taken the complement earlier than the meal, you may trigger indigestion. Usually you may wait out these signs with no situation, however when you really feel they’re too extreme, please get emergency medical consideration as quickly as attainable. 

Ought to I take betaine HCl if I’m taking different drugs? As a consequence of betaine HCl rising the acid within the abdomen, antacids shouldn’t be taken on the identical time, as they are going to debilitate. Equally, Proton-pump Inhibitors (PPIs) and H2-blockers will probably be rendered much less efficient. Particular H2-blockers embody ranitidine (Zantac), cimetidine (Tagamet), famotidine (Pepcid), and nizatidine (Axid). Particular PPIs embody rabeprazole (Aciphex), omeprazole (Prilosec), pantoprazole (Protonix), esomeprazole (Nexium), and lansoprazole (Prevacid).

HCl shouldn’t be taken in case you are utilizing anti-inflammatory drugs like aspirin, ibuprofen, NSAIDs, or Indocin. These drugs can work together and trigger gastrointestinal harm and improve the chance of bleeding or an ulcer. In case you are taking any of those drugs or some other prescribed treatment, please seek the advice of your physician earlier than taking betaine HCl. 

Ought to I take betaine HCl if I’m taking different dietary supplements? There aren’t any notable interactions between betaine HCl and different natural or pure dietary supplements. Please seek the advice of your physician earlier than combining betaine HCl and some other dietary supplements in case you do have an antagonistic response. 

Can betaine HCl trigger ulcers? There’s concern that betaine HCl might doubtlessly irritate abdomen ulcers or forestall them from therapeutic due to the quantity of acid the complement helps produce. Whereas there’s not sufficient proof to counsel that they trigger ulcers, it appears that evidently they’ll affect present ones. In case you have a abdomen ulcer, please seek the advice of your physician earlier than taking this complement. 

What are one of the best manufacturers of betaine HCl in the marketplace? Choosing the proper model for you’ll contain some analysis, and maybe a suggestion out of your physician or pharmacist. If a model has been in the marketplace for some time, and so they have an ideal popularity, you may seemingly belief their product will probably be high-quality. 

A number of the hottest betaine HCl dietary supplements embody betaine HCl 648 mg w/ Protease 120 Vegetable Capsules, Renew Life DigestMORE HCl – HealthBodyNutrition, Solaray Excessive Efficiency HCI With Pepsin, Jamieson Pure Supply Nutrisentials Digestive Enzymes Caplets, and Prairie Naturals Betaine HCL 500mg Plus Peppermint.

When ought to I take betaine HCl? In case you take betaine HCl to fight heartburn, it’s best to all the time take your complement half-way or in direction of the tip of the meal. In case you take it sooner than these two choices, you could possibly amplify the heartburn and scale back the manufacturing of abdomen acid, impacting your physique’s capacity to digest the meal. 

Does betaine HCl fight candida? Betaine HCl can inhibit the overgrowth of power candida. It helps forestall candida from establishing itself within the small gut and wreaking havoc within the physique. There would have to be extra analysis and medical trials to show if betaine HCl can be efficient in treating candida. Please seek the advice of your physician when you endure from candida and wish to take a betaine HCl complement to assist fight it. 

Can betaine HCl assist with meals allergy symptoms? The acid secreted by the abdomen when a meal with protein is consumed might doubtlessly break meals allergens down, so that they’re sufficiently small to be undetectable within the physique, stopping any unfavourable response. 

There are theories that counsel that meals allergy symptoms are amplified by proteins that aren’t absolutely digested, so naturally, betaine HCl might be linked to serving to break these allergens right down to a small quantity. Early analysis suggests this might be the case. Nevertheless, there may be not sufficient analysis to supply concrete proof both method. Medical trials that target betaine HCl as a meals allergen remedy can be required. 

Is betaine HCl appropriate for kids? There’s inadequate proof to counsel betaine HCl is acceptable for kids, so don’t administer it to them with out the recommendation of their physician. They will run exams to diagnose your baby if wanted. 

What occurs if betaine HCl doesn’t work? Usually, there are particular the explanation why betaine HCl doesn’t work. The primary motive is that you could be be taking it once you’re not alleged to. In case you are on different drugs, they might work together with the complement, inflicting it to not work, or inflicting different harm to the physique. The second motive is that you simply is likely to be taking betaine HCl with the improper meals. 

In case you are not digesting protein and also you’ve taken the complement, you’ll seemingly have painful heartburn because of this. The third motive is that you’re not taking an applicable dose. You need to seek the advice of your physician to find out the right dose for you. There’s a median guideline, however most individuals find yourself being above or under that threshold. 

Can betaine HCl trigger weight reduction or weight acquire? Analysis means that people who battle with insufficient abdomen acid could have an effect on how troublesome it’s to drop a few pounds. Correcting that drawback could lead to simpler weight reduction, however the proof is missing to verify this. In case you are searching for an answer to assist your weight reduction and wish to attempt betaine HCl, please contact your physician to get identified to make sure you require it earlier than taking it. 

Can betaine HCl trigger complications? There’s no clear proof to counsel that betaine HCl would possibly trigger complications or migraines, however every particular person is totally different. Some customers of the complement have claimed that their migraines lessened after being launched to betaine HCl. In some analysis, general well being is closely reliant on intestine well being, so it’s a chance. In case you discover there is a rise in complications after taking betaine HCl, please seek the advice of your physician. 

Does betaine HCl scale back joint ache? On this 2016 examine, one man who began taking betaine HCl for acid reflux disorder and irritation, and reported his power knee ache because of three surgical procedures was improved after taking the complement (7). Whereas that is one examine that’s fairly restricted, additional research and medical trials with bigger teams can be wanted to conclude that betaine HCl improves joint ache. 

How lengthy does it take for betaine HCl to take impact? Betaine HCl is comparatively fast-acting. Try to be taking your complement in the midst of your meal or close to the tip to ensure that it to take impact when the physique begins to digest your meal. It is going to begin working inside half-hour of taking the complement. 

Ought to I discover a betaine HCl complement with pepsin? There are a lot of dietary supplements in the marketplace that do and don’t embody Pepsin. Usually, if the physique doesn’t produce sufficient abdomen acid, it’s seemingly that the abdomen won’t produce sufficient Pepsin as nicely. Pepsin is required to interrupt proteins down into peptides to be correctly absorbed and utilized by the physique. 

Taking a stand-alone betaine HCl might presumably be useful for remedy, however that must be decided by your physician. Your doctor can decide when you require a complement that features Pepsin, and may counsel an applicable one. In case you select a complement with out Pepsin and also you require it, you could possibly be lacking out on vital advantages, vitamins, and also you is probably not getting the total aid you require. 

Associated articles


Betaine HCl is a straightforward and simple approach to quickly improve the acidity ranges in your abdomen. When taken by way of a capsule, betaine HCl begins working inside quarter-hour, and its results final for about an hour and quarter-hour.

After that, your abdomen acid ranges will return to regular. In case you are taking it for digesting a meal, this implies you’ve got a couple of 90 minute window after taking the complement the place your digestion will probably be working most successfully.

Pepsin could assist with digestion if it’s added to a betaine HCl complement, although the proof supporting it’s much less sturdy than that of betaine HCl alone. Nevertheless, when you do take pepsin, you positively wish to take it within the presence of betaine HCl, as pepsin received’t work optimally in case your abdomen acid is just not sturdy sufficient.

By way of unwanted effects, folks with acid reflux disorder illness must be hesitant earlier than taking a betaine HCl complement with pepsin, as a result of pepsin seems to be the true perpetrator for a lot of the harm prompted to the esophagus in acid reflux disorder illness.

For dosing, beginning at a degree of 500 to 650 mg appears to be a very good place to begin, although some research on the acute results of betaine HCl on abdomen acidity have used doses of as much as 1500 mg without delay. If low abdomen acidity is inflicting digestive issues, betaine HCl, presumably mixed with pepsin, might be the repair your are searching for.

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