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Rating the most effective TMG dietary supplements of 2021

TMG, quick for trimethylglycine, is a biologically lively compound typically often known as betaine that may be taken for coronary heart well being, liver well being, and improved athletic efficiency in each power and endurance occasions.

It’s present in ample portions in spinach, quinoa, and seafood, however can be obtainable as a complement. For optimum well being and efficiency, holding your physique’s TMG ranges excessive is a worthy aim.

Listed below are the ten greatest TMG dietary supplements in the marketplace, ranked in keeping with high quality.


1. Nutricost TMG

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Nutricost TMG capsules are a fantastic alternative for a easy TMG complement with a average dosage.

At 750 mg, delivered in a gelatin capsule and with none further elements save for rice flour, it is a superb and dependable TMG complement for nearly everyone.

2. Life Extension TMG

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Life Extension TMG has a average dose and a easy elements record. Every gelatin capsule comprises 500 mg of TMG, and, apart from cellulose and water, zero further elements.

If you don’t want a super-high dosage, Life Extension TMG is a glorious alternative.

3. Glorifikation Liposomal NMN + Resveratrol + TMG

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Glorifikation makes a TMG / NMN combo complement that’s specifically tailor-made for anti-aging and antioxidant functions. It combines a 500 mg dosage of each TMG and NMN with a 1200 mg dose of the potent antioxidant resveratrol (present in superfoods like cocoa and pink wine). Although it’s not the best choice for athletes, it’s nice for older adults.

4. NOW Meals Further Energy TMG

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NOW Meals Further Energy TMG comprises 1000 mg of TMG per capsule, in anhydrous type, and whereas it’s fairly well-liked, the elements record is a bit longer than needed.  That apart, it’s one of many few high-dose capsule-based TMG dietary supplements in the marketplace. 

It’s nonetheless a reasonably strong complement but it surely might do with out a few of the stabilizers.  

5. BulkSupplements Pure Betaine Anhydrous Trimethylglycine

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For prime-dose customers, or for anybody who needs to combine TMG into their very own custom-made shake or smoothie powder base, BulkSupplements is the best way to go.

Measuring out the unfastened powder your self generally is a ache, and does require a precision scale for correct dosing, but it surely’s onerous to beat BulkSupplements for those who undergo a considerable amount of TMG frequently.

6. Allergy Analysis Group TMG

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Allergy Analysis Group is a smaller, extra specialised complement producer that makes a TMG complement with 750 mg of TMG per capsule.

The complement ingredient formulation is common; it’s received a few additional elements, however nothing extreme. It’s an okay alternative for a center of the street dosage.

7. Kirkman TMG Liquid

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For many who don’t need to hassle with capsules, or for many who need extra exact management over their TMG dosing, Kirkman presents a novel answer.

This liquid TMG complement dissolves TMG in water and provides some flavoring and sweetening brokers to make it style higher. It’s calorie-free, however that’s as a result of it makes use of the sugar substitute sorbitol.

Nonetheless, it’s a favourite to be used with individuals who can’t or received’t take capsule-based dietary supplements as a result of it’s very straightforward to manage.

8. Nutracost Betaine Anhydrous Trimethylglycine

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Along with its capsule-based dietary supplements, Nutracost makes a powder-form TMG complement for bulk customers. Sadly, this complement doesn’t fairly stack up.

The presence of silicon dioxide and calcium silicate negates one of many main benefits of getting a powder primarily based complement as an alternative of a capsule primarily based one; specifically, the higher purity. Most individuals can be higher off with a unique powder-based TMG, or Nutracost’s personal capsule-based type.

9. Swanson TMG

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Swanson TMG is a reasonably common TMG complement. Every capsule has 500 mg of TMG, and its elements record is a bit bloated with extra fillers and binders than needed.

It’s onerous to rank this TMG complement a lot larger attributable to its incapability to differentiate itself from the group.

10. Kirkman TMG

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Kirkman TMG has a reasonably customary 500 mg dosage of TMG, and in addition consists of folate and vitamin B12. Whereas this can be a good combo if you realize you might be particularly in search of these two different dietary supplements, the use circumstances don’t overlap a lot, so for many customers a TMG-focused complement can be a better option.

Class winners

Finest TMG total: Nutricost TMG

Whether or not your aim is perfect well being or optimum efficiency, you’ll be able to’t go incorrect with Nutricost TMG. With a easy formulation and extremely efficient dosage, Nutricost TMG is an extremely versatile TMG complement that’s well-suited for nearly everybody.

Finest TMG for coronary heart well being: Nutricost TMG

Nutricost TMG presents an efficient dosage in a easy bundle—and that’s precisely what you need for cardiovascular well being. At 750 mg per capsule, it will get you 50% extra TMG than a lot of the competitors, with out fillers, bulking brokers, or different dietary supplements coming alongside for the experience.

Finest TMG for anxiousness: Life Extension TMG

TMG is seeing growing use for temper help, and for this function the average dosage and ultra-pure formulation of Life Extension TMG is the right match. With no ancillary elements or different dietary supplements alongside for the experience, you might be certain any calming results you see are instantly attributable to the TMG. 

Finest TMG for liver well being: NOW Meals Further Energy TMG

NOW Meals makes a high-dosage model of their TMG complement that’s particularly tailor-made for supporting liver well being. At 1000 mg per capsule, it delivers sufficient bioactive TMG to considerably upregulate your homocysteine ranges in your liver.

Finest TMG for athletes: Nutricost TMG

Our high total choose can be our high choose for athletes. Because of its highly effective dosage and clear formulation, Nutricost TMG is well-suited to ship the endurance and cardiovascular perform advantages promised by trimethylglycine. 

Finest TMG with NMN: Glorifikation Liposomal NMN + Resveratrol + TMG

TMG and NMN are a widely-lauded anti-aging formulation, because of the synergistic results of those two biologically lively compounds. Our choose for a TMG/NMN combo is Glorifikation, attributable to its balanced dose of NMN and TMG, plus a hefty quantity of resveratrol for added antioxidant energy.

Who can buy TMG?

TMG is protected for the overwhelming majority of the inhabitants and is nice for enhancing cardiovascular well being, decreasing irritation, and defending your liver from harm. It could actually additionally drastically scale back excessive homocysteine ranges, which have been related to varied illnesses, together with osteoporosis and coronary heart illness. 

Because of the lack of analysis, pregnant ladies and youngsters ought to keep away from TMG till extra conclusive proof surfaces concerning the security in these populations. Folks with ldl cholesterol points must also keep away from TMG because it has been proven to extend LDL and complete ldl cholesterol in some circumstances. 

Athletes have been recognized to take TMG because it has been proven (slightly unreliably) to spice up efficiency when taken at doses of two.5g per day. Whereas there are not any drugs that work together with TMG, you need to nonetheless communicate to your physician earlier than beginning a TMG complement routine in case you are at present taking any prescription drugs, to be protected. 

How we ranked

TMG can come below quite a lot of names, together with betaine, Glycine betaine, and oxyneurine, which is why you’ll discover quite a lot of product names on our record. By way of dosages, 1000mg is seen because the minimal efficient dose, with 2.5g seen because the tipping level (particularly for larger folks). As such, we most popular merchandise that included no less than 500mg per serving as this supplies the best choice for each tailoring the dose and titration for newbies. That is the primary cause why Life Extension ranked in our high 5. 

Subsequent, we checked out purity. We wished all of the merchandise on our record to have minimal fillers, binders, components, and coloring brokers. Something that included extreme quantities of those had been both axed or severely penalized when it comes to rankings. Merchandise like Nutricost TMG ranked properly right here for offering a product with only one ingredient: TMG.

TMG dietary supplements are available 2 principal types: capsule type and powder. By way of effectiveness, they’re each pretty equal, however we did have a slight choice for capsule-based merchandise. The primary cause for this was the accuracy of dosing and comfort, which is why merchandise like Nutricost took the highest spot over extra pure merchandise like Bulk Dietary supplements TMG powder. For capsules, we did have a slight choice for cellulose-based ones over gelatin ones. This was extra to keep away from frequent allergens and wasn’t a deal-breaker in lots of circumstances.

On our record, you’ll additionally discover a liquid TMG complement. Whereas it’s straightforward to manage, it does comprise extra flavoring brokers than we’d like. It is usually unclear how even the dose is per serving in addition to if the water it’s included in makes the TMG much less efficient. That is why the Kirkland TMG liquid ranked in our backside 5. 


TMG can enhance cardiovascular well being by lowering homocysteine. Homocysteine is an amino acid, but it surely’s not one of many important amino acids that you just get from meals. As a substitute, it’s a metabolic precursor to different compounds your physique wants.

When homocysteine ranges get too excessive, they will trigger harm and irritation to the cells that line the within of your blood vessels. TMG, in flip, can scale back homocysteine ranges. That makes it—theoretically no less than—a possible protecting agent for coronary heart well being.

Analysis backs up this speculation: in keeping with a scientific overview article by Per Magne Ueland on the College of Bergen in Norway, scientific research have discovered a hyperlink between low ranges of TMG within the blood and heart problems danger elements (1).

The cardiovascular advantages of decreasing homocysteine with TMG are blunted by some unfavorable results on levels of cholesterol. Analysis revealed within the journal PLoS Drugs by a bunch of scientists within the Netherlands discovered that, whereas TMG does decrease ranges of homocysteine, and thus improves your total heart problems danger profile, it additionally has the tendency to lift your LDL ldl cholesterol (2).

LDL ldl cholesterol colloquially often known as “dangerous” ldl cholesterol as a result of excessive ranges of it have been linked to coronary heart illness. This most likely implies that TMG is a poor alternative for individuals who have excessive ldl cholesterol already, however as identified by S.H. Zeisel on the College of North Carolina at Chapel Hill, the homocysteine/LDL commerce off could also be a good one for some folks in terms of decreasing their total danger of coronary heart illness (3).

TMG might scale back the inflammatory issues related to weight problems. One of many largest causes that weight problems is a menace to well being just isn’t a lot the additional weight and fats, per se.

It’s the truth that the excessive ranges of fats create power, low-grade irritation in your physique. That is the supply of the most important threats to well being from weight problems: kind two diabetes, coronary heart illness, and most cancers (4).

Current analysis from researchers in Finland that was revealed in 2013 within the British Journal of Diet means that TMG might assist tamp down on the irritation related to weight problems.

Utilizing cultures of human fats cells, the researchers confirmed that fats cells uncovered to TMG produced fewer pro-inflammatory compounds. Whereas a TMG complement might not assist with weight reduction instantly, taking TMG might scale back a few of the unfavorable well being results of being obese, thereby dashing your return to well being.

TMG may help defend your liver from harm. One trigger of significant liver harm and liver illness is the buildup of fatty acids in liver tissue. Scientific research have discovered that TMG actively fights the buildup of fats within the liver, and could possibly be used to enhance liver well being.

Fatty liver illness might be brought on both by power and extreme alcohol consumption or by weight problems and excessive dietary consumption of sugar, however the results are the identical.

One research revealed within the journal Alcoholism, Medical and Experimental Analysis in 1997 demonstrated {that a} TMG complement fed to rats might reverse the harm to the liver attributable to extreme alcohol consumption (5).

Apparently, the homocysteine pathway we noticed earlier in relation to coronary heart illness reappears in liver illness too. Different analysis has related excessive homocysteine ranges with liver harm and liver illness, and since TMG is thought to lower ranges of homocysteine, it’s been investigated as a possible agent for treating and even stopping harm to the liver (6).

TMG can enhance train efficiency. Thanks presumably to its function in DNA restore, TMG reveals robust proof of a performance-enhancing impact in each resistance and endurance train.

Based on analysis revealed in 2011 within the Journal of Energy and Conditioning Analysis, TMG can enhance muscular oxygen consumption, thereby growing variety of lifts to fatigue in resistance coaching (7). The research demonstrated {that a} 2.5 gram dose of TMG elevated variety of reps to failure, in addition to complete quantity of weight moved.

The researchers drew a direct connection between the advance in lifting efficiency and the superior ranges of muscular oxygen uptake. Different analysis has discovered that TMG could possibly be helpful in endurance efficiency too. A overview research by Stuart Craig revealed within the American Journal of Medical Diet cites analysis exhibiting that TMG supplementation improves repeated dash efficiency and improves each cardio and anaerobic metabolism (8).

Apparently, TMG seems to be significantly efficient at augmenting endurance efficiency in very popular situations, although it’s not clear why. That is an space of lively analysis.

Uncomfortable side effects

TMG is present in pretty excessive concentrations in lots of wholesome meals—spinach and quinoa, for instance, are practically 1% betaine by weight.

As such, even pretty excessive doses of TMG are unlikely to trigger any acute uncomfortable side effects (no less than to no higher extent than consuming plenty of quinoa or spinach would.

The first antagonistic impact to pay attention to is the previously-mentioned long-term results on LDL ldl cholesterol stage. TMG just isn’t the most effective complement for individuals who know they’ve excessive ldl cholesterol, except you’re particularly instructed to take TMG by your physician. Individuals who match this description would possibly need to select a unique complement for coronary heart well being, similar to fiber or fish oil.

Really useful dose

Direct suggestions on TMG dosage from scientific trials are missing, but it surely’s potential to derive some pointers from different analysis and data about TMG. Some researchers have estimated that the common particular person will get wherever from 0.5 to 2.5 grams of TMG per day in a typical weight loss plan (9).

The identical research means that fast and substantial drops in homocysteine might be achieved by doses of six grams of TMG per day, although contemplating the everyday particular person’s each day consumption, beginning with a dose extra like one to 2 grams of TMG per day must be efficient (this is able to signify a doubling of the everyday particular person’s consumption).

The excessive finish of this vary can be in keeping with the TMG doses utilized in research on train efficiency.


What does TMG stand for? TMG stands for Trimethylglycine however can be generally often known as Betaine anhydrous.

What occurs if I take an excessive amount of TMG? It’s tough to take an excessive amount of TMG, and for those who do, the outcomes might be tough to detect. Nonetheless, for those who take a big dose and also you begin to really feel fatigued, nauseous, dizziness, hair loss, or a basic feeling of unwellness, your physique could also be delicate to bigger doses. Some folks want a smaller dose to really feel the results of TMG. If you happen to really feel that you just’ve taken an excessive amount of TMG, please contact your physician, or for extra fast medical consideration, contact poison management or go to your nearest emergency room. 

Ought to I take TMG if I’m taking different drugs? There are not any notable interactions between drugs and TMG dietary supplements. Nonetheless, for those who’re at present taking any prescription remedy, over-the-counter medicine, or have any well being situations, please seek the advice of your physician earlier than including a TMG complement into your weight loss plan. 

Ought to I take TMG if I’m taking different dietary supplements? There are not any notable interactions between TMG and different pure dietary supplements, however please seek the advice of your physician earlier than combining a number of dietary supplements, as they will negatively work together in a different way relying on the person. 

Is TMG an acceptable therapy for Homocystinuria? There may be analysis to counsel that taking TMG will lower the degrees of homocysteine within the blood for some people. It’s not completely evident if it impacts the chance of coronary heart illness together with this. It’s generally believed that combining TMG with a Folate complement is a simpler method to lowering these ranges, however there isn’t any proof to counsel that it’s true. 

Is TMG appropriate for youngsters? Kids can take TMG safely with a dosage really useful by a medical skilled primarily based on their top and weight. TMG just isn’t appropriate for infants. When treating Homocystinuria in youngsters below three, the dosage must be elevated steadily.

Beginning with 100mg per kg of physique weight per day for every week, then 200 mg per kg for every week, after which 300 mg per kg per day till their prescribed upkeep dose is reached. Till the blood ranges of homocysteine are low or onerous to detect, your doctor might enhance the dose by 20 grams per day to realize this. 

What occurs if I’m allergic to TMG? Chances are you’ll expertise typical allergic reactions for those who occur to be allergic to TMG, which is uncommon. If you happen to really feel unwell, have developed a rash, have itchiness, dizziness, or swelling in your face, throat, or nostril, you may be having an allergic response. Please go to your nearest emergency room to obtain fast medical consideration. 

What’s TMG primarily used for? Trimethylglycine, or TMG for brief, is an important a part of your physique’s DNA safety and restore mechanism. It’s useful for organ well being; it improves every little thing from coronary heart perform to kidney perform. Rising analysis additionally means that the identical mechanism might make TMG useful for enhancing train efficiency and for treating melancholy.

How do I do know if TMG is correct for me? You probably have excessive homocysteine ranges in your urine, TMG is efficient for lowering and treating this concern. TMG can be utilized in sorts of toothpaste to assist deal with and forestall dry mouth signs.

The opposite generally believed remedies linked to TMG, together with lowering the chance of cancers, lowering the lively virus of Hepatitis C, treating liver illness, or treating sunburns do not need sufficient proof to counsel proof that TMG may help. You probably have any of those points and need to begin taking a TMG complement, please seek the advice of your physician. 

What’s the greatest model of TMG? Selecting a complement from a model that’s respected and highly-reviewed is a private alternative. Doing analysis on well-liked manufacturers, or asking your physician or pharmacist for a suggestion might be an effective way to decide on a complement. 

A few of the hottest dietary supplements embrace NOW Meals TMG 1000 mg 100 Tablets, NOW Meals TMG (Trimethylglycine), Genestra TMG 120 Veggie Caps from Wholesome Planet, Piping Rock Well being Dietary supplements TMG (Trimethylglycine), and Genestra Manufacturers Naturally Northern TMG.

Can I take advantage of TMG if I’m pregnant or breastfeeding? There may be not sufficient proof to show both method whether or not TMG is appropriate for pregnant or breastfeeding ladies, so it’s suggested to err on the aspect of warning and keep away from taking any frequent dietary supplements when anticipating. 

Can TMG trigger complications? Some people are very delicate to TMG, and taking a traditional dosage might result in feeling unwell or inflicting complications. Every particular person might tolerate the complement in a different way, so for those who discover you might be having persistent complications, please talk about this together with your physician. 

Can TMG improve anxiousness? TMG works to extend S-adenosyl-methionine or SAMe, which might enhance the manufacturing of serotonin, norepinephrine, and dopamine. This implies that TMG has a constructive impression on psychological well being points. There may be not ample proof that TMG can impression or treatment anxiousness, however there isn’t any proof to counsel that it enhances the sensation of anxiousness. 

When ought to I take TMG? Taking TMG after your meal, ready no less than two hours, is good. If you happen to take it too near consuming, the complement and your meal can compete for absorption into the physique, making it much less efficient or blocking out different priceless vitamins. 

Is TMG efficient for folks with autism? It’s theorized that youngsters on the spectrum might have methionine cycles that current in an irregular method. This cycle aids within the formation of blood vessels and different pathways, and an abnormality might trigger quite a lot of cognitive issues. This concept is unproven and requires additional analysis. Some researchers theorize that youngsters on the spectrum have low ranges of the by-products which might be required for this cycle, and they’re in danger for oxidative stress.

In youngsters with Autism, TMG deficiency and Choline deficiency can contribute to the low ranges of methionine, which have an effect on the irregular gene expression. Researchers usually are not certain if TMG can impression the SAMe (S-adenosyl-methionine) ranges in youngsters with autism, however scientific trials have proven constructive leads to wholesome contributors.

A small scientific trial advised that TMG and folinic acid mixed to normalize the methionine cycle in autistic youngsters, and TMG elevated antioxidant ranges. This was just one research, so additional analysis and testing are required to find out all the potential results of TMG in autistic youngsters. 

Can TMG assist stop acid reflux disease? Analysis has proven that taking a TMG complement together with L-tryptophan, Nutritional vitamins B6 and B12, Folic acid, Melatonin, and methionine each day could possibly scale back the signs of acid reflux disease. 

Can I take advantage of TMG as a pre-workout? TMG is a generally added ingredient to many well-liked exercise dietary supplements. There are research to indicate that TMG dietary supplements might enhance a person’s total physique, but it surely have to be accompanied by train, because it doesn’t work by itself.

In scientific trials of those dietary supplements, two specific research reported that there was a constructive enhance in power and energy, however additional research can be required to substantiate these outcomes. In two research of lively males, the TMG complement allowed them to extend their repetitions throughout a exercise.

It’s potential that TMG might even enhance endurance, scale back fatigue throughout train, and enhance total health. TMG might not give the everyday increase {that a} pre-workout would, but it surely’s potential that it might have constructive results on efficiency. Seek the advice of your physician earlier than taking this complement earlier than train, and don’t take your first dose earlier than a exercise to make sure you can tolerate TMG, and also you’re not delicate to it.

Does TMG result in melancholy? There have been scientific research that counsel TMG may help reduce the signs of melancholy in sufferers who don’t reply to antidepressants. In a single research, 45 sufferers affected by melancholy used TMG and SAMe as further therapies for 90 days, and lots of of them claimed it diminished anxiousness and emotions of worthlessness and helplessness (10). 

This was one research, and additional analysis is required to substantiate these outcomes. In rats, researchers have seen that TMG considerably modified their habits whereas growing norepinephrine and serotonin ranges within the depressed rats’ brains. The TMG mimicked the impact of an antidepressant. These research haven’t but been replicated in people. 

Does TMG trigger unfavorable results on the kidneys? TMG works to make sure the cells within the kidneys keep hydrated. When the cells are below stress, TMG aids in preserving the quantity of the cell with out impacting the perform of the kidneys. Medical trials have been accomplished with mice and rats, and including a TMG complement helped defend the kidneys from harm when there have been excessive uric acid ranges.

In rats, TMG labored to guard the kidneys when there was CCL4-induced toxicity. CCL4 could cause cirrhosis of the liver and cell loss of life within the kidneys. There would should be extra analysis and human scientific trials to find out what constructive results TMG has on the kidneys. 

How does TMG have an effect on ldl cholesterol? TMG might enhance the quantity of LDL ldl cholesterol within the physique, no matter well being standing. Wholesome people, overweight people, and people with underlying well being situations. You probably have excessive ldl cholesterol, utilizing TMG cautiously with the supervision of your physician is essential. 

Associated Articles


TMG is a naturally-occurring substance that may assist enhance coronary heart well being, scale back irritation related to weight problems, and presumably enhance athletic efficiency.

The analysis supporting its use is pretty new, so agency pointers on dosing are onerous to come back by, however a each day dose of 0.5 to 2.5 grams of TMG looks like a great place to start out.

The upper finish of the dosage stage appears most helpful for enhancing train efficiency. Because it’s present in excessive concentrations in lots of meals, most individuals don’t have to fret about antagonistic results. The one exception to that is individuals who have excessive ldl cholesterol, as TMG might elevate your LDL ldl cholesterol. On this case, you would possibly need to try different dietary supplements which have a extra constant across-the-board profit for coronary heart well being, like fish oil.

As a result of it’s concerned in biochemical processes which might be on the core of nearly each organic perform, it’s no surprise TMG dietary supplements have such a flexible vary of functions.

For BodyNutrition’s #1 really useful TMG complement, click on right here.

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